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One of the rarest resources in Dragon's Dogma 2 is the Wyrmslife Crystal. Obtained from defeating beasts such as Drakes, Ogres, and Minotaurs, this calcified drop of blood is important to come by in the game. Farming them takes some time, especially since they are end-game items, but along the way, make sure to store as many as you can before using them up.
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